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  • Evidence is increasing that all addiction without exception is related to problems with the brain's reward center, specially the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, plus nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to shed pounds can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the people that go through it you need to err to the side of caution and let the FDA do its job and demand some study be done so your public understands the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies will be in business to earn money and that they would say everything to keep people on their own medications.

    Researchers found that participants investing in this drug to get a year, dropped a few pounds within one month and have kept the body weight off during the entire 56 weeks in the study. Contrave can be a combination with the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which are made up of several active ingredient, that might make them more efficient and safer.

    Combo-pilling will be the newest fad or in addition to this the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is becoming popular will be the fact that as of right now there aren't any long term prescription weight loss supplements that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.

    Seizures certainly are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug could also raise blood pressure and heartrate, and must not be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not used in patients with uncontrolled high blood pressure, in addition to by you are not heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients for the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.

    Acamprosate also actively works to eliminate the want to drink by reducing the the cravings for drinking alcohol. The major difference between Naltrexone and Acamprosate is the fact that Acamprosate is just not yet accessible in the United States. While it continues to be widely studied in Europe the complete chemical reason why it works remains to be unknown. It is believed that it disturbs receptors inside brain which process glutamate, which in place alters the best way ones body reacts to alcohol intake. Several of the European studies show a lot of promise with Acamprosate in this some of the patients had a nearly double effectiveness for staying sober.

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